Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP6 | P51161 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 10/20 | 0.37 |
| ▸ | JAK2 | O60674 | 7/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.34 |
| ▸ | ROS1 | P08922 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22131521 | 0.81 | FABP6 (0.51) | FABP6GSK3BNTRK1JAK2MAPKAPK2 | |
| SCHEMBL18237530 | 0.79 | ALDH1A1 (0.46) | KDM4E | |
| SCHEMBL18237989 | 0.78 | MAOB (0.41) | — | |
| SCHEMBL18237836 | 0.76 | ALDH1A1 (0.42) | KDM4E | |
| SCHEMBL18238060 | 0.75 | PARP10 (0.47) | KDM4E | |
| SCHEMBL13392164 | 0.74 | FABP6 (0.61) | FABP6GSK3BNTRK1JAK2MAPKAPK2 | |
| SCHEMBL2669110 | 0.72 | FABP6 (0.48) | FABP6GSK3BNTRK1JAK2MAPKAPK2 | |
| SCHEMBL18237940 | 0.72 | PARP10 (0.47) | KDM4E | |
| SCHEMBL13306173 | 0.71 | PTGS1 (0.35) | KDM4E | |
| SCHEMBL22607395 | 0.71 | CLK4 (0.38) | GSK3BNTRK1JAK2NTRK2NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180079727-A1 | 9-MEMBERED FUSED RING DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2018-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180079727-A1 | 9-MEMBERED FUSED RING DERIVATIVE | ACSS2, AGTR2, ACSL3 | FABP6 2548/4885GSK3B 2144/4885NTRK1 4251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.