SCHEMBL19984615

SCHEMBL19984615

CNC(c1ccccc1)c1cccc(OCc2cccc(C=O)c2)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 0.61
MAOA P21397 8/20 0.61
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
TDP1 Q9NUW8 1/20 0.50
CCNB2 O95067 1/20 0.47
CDK1 P06493 1/20 0.47
CDK4 P11802 1/20 0.47
CCNB1 P14635 1/20 0.47
CCND1 P24385 1/20 0.47
CCNB3 Q8WWL7 1/20 0.47
BCHE P06276 2/20 0.46
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
PKM P14618 1/20 0.46
KMT2A Q03164 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
LCK P06239 1/20 0.43
SGMS2 Q8NHU3 1/20 0.43
TLR4 O00206 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19903853 0.89 MAOB (0.56) MAOBMAOANPC1RAB9ATDP1
SCHEMBL20373825 0.86 MAOA (0.59) MAOBMAOANPC1RAB9ATDP1
SCHEMBL19903890 0.81 ERN1 (0.47) MAOBMAOANPC1RAB9ATDP1
SCHEMBL3083923 0.80 MAOA (0.81) MAOBMAOANPC1RAB9ATDP1
SCHEMBL314161 0.77 MAOB (1.00) MAOBMAOANPC1RAB9ATDP1
SCHEMBL29454637 0.77 MAOB (1.00) MAOBMAOANPC1RAB9ATDP1
SCHEMBL19984677 0.77 RXRA (0.57) MAOBKMT2ASMN1; SMN2
SCHEMBL19903884 0.75 MAOA (0.53) MAOBMAOANPC1RAB9ATDP1
SCHEMBL10360890 0.74 MAOA (0.54) MAOBMAOANPC1RAB9ATDP1
SCHEMBL9454264 0.72 MAOB (0.89) MAOBMAOANPC1RAB9ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2928889-B1 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY CHIESI FARM SPA (IT) 2018-03-21 EP disclosed