Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.32 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21291392 | 0.88 | SLC22A12 (0.36) | SLC22A12PDPK1EGLN1ROCK2BACE1 | |
| SCHEMBL19984758 | 0.85 | EGLN1 (0.41) | EGLN1ROCK2 | |
| SCHEMBL18667022 | 0.81 | EGLN1 (0.38) | PDPK1EGLN1BACE1KLKB1THRB | |
| SCHEMBL19984576 | 0.78 | ROCK2 (0.38) | ROCK2 | |
| SCHEMBL18667510 | 0.77 | EGLN1 (0.40) | PDPK1EGLN1BACE1THRB | |
| SCHEMBL18667774 | 0.76 | TP53 (0.48) | EGLN1THRB | |
| SCHEMBL21291308 | 0.76 | EGLN1 (0.40) | SLC22A12PDPK1EGLN1ROCK2KLKB1 | |
| SCHEMBL21291409 | 0.76 | EGLN1 (0.42) | EGLN1ROCK2KLKB1 | |
| SCHEMBL21250425 | 0.74 | EGLN1 (0.38) | PDPK1EGLN1BACE1THRB | |
| SCHEMBL18667518 | 0.73 | ALDH1A1 (0.36) | PDPK1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053157-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES, INC. (US) | 2018-03-22 | — | — | WO | disclosed |