Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16313486 | 0.82 | POLB (0.57) | GSK3BPOLBKMT2AERCC5FEN1 | |
| SCHEMBL19984698 | 0.80 | GSK3B (0.53) | GSK3BPOLBKMT2AL3MBTL1MAPT | |
| SCHEMBL6904340 | 0.79 | GSK3B (0.50) | GSK3BPOLBKMT2AERCC5FEN1 | |
| SCHEMBL6900441 | 0.79 | GSK3B (0.50) | GSK3BPOLBKMT2AERCC5FEN1 | |
| SCHEMBL1548812 | 0.78 | KMO (0.67) | GSK3BPOLBKMT2AERCC5FEN1 | |
| SCHEMBL14889161 | 0.78 | KMO (0.67) | GSK3BPOLBKMT2AERCC5FEN1 | |
| SCHEMBL19984703 | 0.78 | ERCC5 (0.54) | KMT2AERCC5FEN1CYP2C19 | |
| SCHEMBL19642630 | 0.78 | GSK3B (0.61) | GSK3BPOLBKMT2AERCC5FEN1 | |
| SCHEMBL6410944 | 0.78 | POLB (0.60) | GSK3BPOLBKMT2AERCC5FEN1 | |
| SCHEMBL5254933 | 0.76 | GSK3B (0.67) | GSK3BERCC5FEN1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306986-B1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | PROLYNX LLC (US) | 2018-03-21 | — | — | EP | disclosed |