Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.54 |
| ▸ | FEN1 | P39748 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.42 |
| ▸ | CHRNG | P07510 | 1/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3675550 | 0.83 | KMO (0.66) | ERCC5FEN1MEN1KMT2APARP1 | |
| SCHEMBL7406071 | 0.83 | KMO (0.66) | ERCC5FEN1MEN1KMT2APARP1 | |
| SCHEMBL19984713 | 0.83 | ERCC5 (0.54) | ERCC5FEN1MEN1KMT2APARP1 | |
| SCHEMBL728409 | 0.83 | KMO (0.66) | ERCC5FEN1MEN1KMT2APARP1 | |
| SCHEMBL13647196 | 0.81 | ERCC5 (0.56) | ERCC5FEN1MEN1KMT2APARP1 | |
| SCHEMBL1266993 | 0.80 | ERCC5 (0.62) | ERCC5FEN1MEN1KMT2APARP1 | |
| SCHEMBL19984837 | 0.79 | MEN1 (0.51) | MEN1KMT2APARP1HPGDKCNH2 | |
| SCHEMBL13977660 | 0.78 | ERCC5 (0.61) | ERCC5FEN1MEN1KMT2APARP1 | |
| SCHEMBL19984701 | 0.78 | GSK3B (0.55) | ERCC5FEN1KMT2ACYP2C19 | |
| SCHEMBL11791699 | 0.77 | ERCC5 (0.76) | ERCC5FEN1MEN1KMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306986-B1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | PROLYNX LLC (US) | 2018-03-21 | — | — | EP | disclosed |