Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19984778 | 0.84 | TSHR (0.54) | TSHRLMNAMAPTCYP2C9MAPK1 | |
| SCHEMBL19984685 | 0.84 | TSHR (0.46) | MAOAMAOBTSHRCYP2D6CYP2C9 | |
| SCHEMBL15617657 | 0.82 | MAOA (0.47) | MAOAMAOBTSHRLMNAMAPT | |
| SCHEMBL1348988 | 0.81 | MAOA (0.53) | MAOAMAOBTSHRLMNAMAPT | |
| SCHEMBL13567533 | 0.78 | MAOA (0.43) | MAOAMAOBTSHRLMNAMAPT | |
| SCHEMBL19984686 | 0.77 | IDO1 (0.47) | TSHRLMNAMAPTCYP2D6CYP2C9 | |
| SCHEMBL72752 | 0.76 | — | — | |
| Water SCHEMBL27942269 | 0.76 | MAOA (0.73) | MAOAMAOBTSHRLMNAMAPT | |
| SCHEMBL2518114 | 0.75 | MAOA (0.55) | MAOAMAOBTSHRLMNAMAPT | |
| Fluoride SCHEMBL27481173 | 0.73 | MAOA (0.70) | MAOAMAOBTSHRLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306986-B1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | PROLYNX LLC (US) | 2018-03-21 | — | — | EP | disclosed |