Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | TDO2 | P48775 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19984778 | 0.91 | TSHR (0.54) | IDO1TDO2TSHRHIF1AMAPK1 | |
| SCHEMBL19984820 | 0.87 | LMNA (0.44) | TSHRHIF1AMAPK1ADRA2AKDM4E | |
| SCHEMBL15617669 | 0.79 | SLC6A2 (0.49) | IDO1TDO2TSHRHIF1AMAPK1 | |
| SCHEMBL29001567 | 0.79 | IDO1 (0.52) | IDO1TDO2TSHRHIF1AMAPK1 | |
| SCHEMBL19984819 | 0.79 | LMNA (0.44) | TSHRHIF1AADRA2ACNR1KDM4E | |
| SCHEMBL477349 | 0.78 | IDO1 (0.54) | IDO1TDO2TSHRSLC6A2SLC6A4 | |
| SCHEMBL477552 | 0.78 | IDO1 (0.54) | IDO1TDO2TSHRSLC6A2SLC6A4 | |
| SCHEMBL6874895 | 0.78 | SLC6A2 (0.59) | IDO1TDO2TSHRHIF1ASLC6A2 | |
| SCHEMBL477379 | 0.78 | IDO1 (0.54) | IDO1TDO2TSHRSLC6A2SLC6A4 | |
| SCHEMBL12153197 | 0.78 | IDO1 (0.54) | IDO1TDO2TSHRHIF1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306986-B1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | PROLYNX LLC (US) | 2018-03-21 | — | — | EP | disclosed |