Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19984686 | 0.91 | IDO1 (0.47) | TSHRHIF1AMAPK1TDP1BRD4 | |
| SCHEMBL19984901 | 0.84 | CNR2 (0.50) | TSHRHIF1AMAPK1TDP1BRD4 | |
| SCHEMBL19984902 | 0.84 | MAOA (0.47) | TSHRHIF1AMAPK1TDP1BRD4 | |
| SCHEMBL19287471 | 0.79 | TSHR (0.46) | TSHRHIF1AMAPK1TDP1BRD4 | |
| SCHEMBL15617719 | 0.75 | TSHR (0.54) | TSHRHIF1AMAPK1TDP1BRD4 | |
| SCHEMBL19984820 | 0.74 | LMNA (0.44) | TSHRHIF1AMAPK1LMNAKDM4E | |
| SCHEMBL1426754 | 0.73 | TSHR (0.50) | TSHRHIF1AMAPK1TDP1BRD4 | |
| SCHEMBL10654649 | 0.73 | TSHR (0.50) | TSHRHIF1AMAPK1TDP1BRD4 | |
| SCHEMBL3688149 | 0.73 | TSHR (0.50) | TSHRHIF1AMAPK1TDP1BRD4 | |
| SCHEMBL11408688 | 0.72 | SLC6A3 (0.47) | HIF1ATDP1BRD4LMNAADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306986-B1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | PROLYNX LLC (US) | 2018-03-21 | — | — | EP | disclosed |