Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | EEF2K | O00418 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19984902 | 0.84 | MAOA (0.47) | TSHRMAOBMAOACYP19A1CYP2D6 | |
| SCHEMBL19984820 | 0.82 | LMNA (0.44) | TSHRCYP2D6 | |
| SCHEMBL15617629 | 0.81 | TSHR (0.46) | TSHROPRD1MAOBMAOACYP19A1 | |
| SCHEMBL16771261 | 0.80 | TSHR (0.54) | TSHROPRD1MAOBMAOACYP19A1 | |
| SCHEMBL11603519 | 0.80 | TSHR (0.54) | TSHROPRD1MAOBMAOACYP19A1 | |
| SCHEMBL5664054 | 0.80 | LSS (0.55) | TSHROPRD1MAOBMAOACYP19A1 | |
| SCHEMBL13567491 | 0.77 | LMNA (0.44) | TSHROPRD1MAOBMAOACYP19A1 | |
| SCHEMBL29038977 | 0.76 | CYP19A1 (0.63) | TSHROPRD1MAOBMAOACYP19A1 | |
| SCHEMBL1343704 | 0.76 | CYP19A1 (0.63) | TSHROPRD1MAOBMAOACYP19A1 | |
| SCHEMBL12260185 | 0.75 | OPRD1 (0.40) | TSHROPRD1MAOBMAOACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306986-B1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | PROLYNX LLC (US) | 2018-03-21 | — | — | EP | disclosed |