SCHEMBL19985039

SCHEMBL19985039

CC1=CC(O/C=C(\C(=O)N(C)C)C2CCc3ccccc32)OC1=O

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 6/20 0.39
PIN1 Q13526 6/20 0.38
PPIB P23284 1/20 0.32
PPIA P62937 1/20 0.32
RAB9A P51151 1/20 0.32
ROCK1 Q13464 1/20 0.32
ACHE P22303 1/20 0.31
CRBN Q96SW2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19984870 1.00 NFE2L2 (0.39) NFE2L2PIN1PPIBPPIARAB9A
SCHEMBL23877351 0.89 NFE2L2 (0.40) NFE2L2PIN1PPIBPPIAROCK1
SCHEMBL19984921 0.88 NFE2L2 (0.39) NFE2L2PIN1PPIBPPIAROCK1
SCHEMBL19984930 0.88 NFE2L2 (0.39) NFE2L2PIN1PPIBPPIAROCK1
SCHEMBL19984924 0.87 PIN1 (0.41) NFE2L2PIN1PPIBPPIAROCK1
SCHEMBL19984944 0.85 NFE2L2 (0.38) NFE2L2PIN1ROCK1
SCHEMBL21538698 0.84 NFE2L2 (0.37) NFE2L2PIN1PPIBPPIA
SCHEMBL21538697 0.83 PIN1 (0.37) PIN1PPIBPPIARAB9A
SCHEMBL21538751 0.79 NFE2L2 (0.37) NFE2L2CRBN
SCHEMBL21538717 0.79 NFE2L2 (0.36) NFE2L2CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3512843-B1 PLANT GROWTH REGULATOR COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-10-20 EP disclosed
US-11136292-B2 Plant growth regulator compounds SYNGENTA PARTICIPATIONS AG (CH) 2021-10-05 US disclosed
US-20190330148-A1 PLANT GROWTH REGULATOR COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2019-10-31 US disclosed
WO-2018050477-A1 PLANT GROWTH REGULATOR COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11136292-B2 Plant growth regulator compounds FGF1, MST1, CDC20 NFE2L2 2365/4885PIN1 2117/4885PPIB 2189/4885
US-20190330148-A1 PLANT GROWTH REGULATOR COMPOUNDS FGF1, MST1, CDC20 NFE2L2 2365/4885PIN1 2117/4885PPIB 2189/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.