Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | FPR1 | P21462 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19985866 | 1.00 | KMT2A (0.46) | KMT2AL3MBTL1ALDH1A1TSHRMAPK1 | |
| SCHEMBL13461299 | 0.93 | KMT2A (0.49) | KMT2AL3MBTL1ALDH1A1TSHRMAPK1 | |
| SCHEMBL13434396 | 0.93 | KMT2A (0.49) | KMT2AL3MBTL1ALDH1A1TSHRMAPK1 | |
| SCHEMBL19985844 | 0.85 | FPR1 (0.45) | KMT2AL3MBTL1ALDH1A1TSHRMAPK1 | |
| SCHEMBL19985865 | 0.84 | KMT2A (0.48) | KMT2AL3MBTL1KDM1AMAOBPDE4B | |
| SCHEMBL6865331 | 0.79 | KMT2A (0.60) | KMT2AL3MBTL1ALDH1A1TSHRMAPK1 | |
| SCHEMBL5425216 | 0.79 | KMT2A (0.60) | KMT2AL3MBTL1ALDH1A1TSHRMAPK1 | |
| SCHEMBL19972384 | 0.78 | FPR1 (0.55) | KMT2AL3MBTL1ALDH1A1PDE4BFPR1 | |
| SCHEMBL19985853 | 0.77 | FPR1 (0.51) | KMT2AL3MBTL1ALDH1A1MAPK1FPR1 | |
| SCHEMBL16780873 | 0.77 | KMT2A (0.52) | KMT2AL3MBTL1KDM1AMAOBPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180078541-A1 | 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL | Grünenthal GmbH (DE) | 2018-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180078541-A1 | 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL | FPR2, FPR1, FPR3 | KMT2A 3931/4885L3MBTL1 4536/4885ALDH1A1 3156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.