Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.59 |
| ▸ | TP53 | P04637 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3338493 | 0.85 | LMNA (0.62) | ALDH1A1RAB9ANPC1TP53LMNA | |
| SCHEMBL18403966 | 0.85 | NCF1 (0.67) | ALDH1A1POLBSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL12038517 | 0.83 | HRH3 (0.69) | ALDH1A1POLBSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL3860591 | 0.83 | HRH3 (0.69) | ALDH1A1POLBSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL28419031 | 0.81 | ALDH1A1 (0.59) | ALDH1A1RAB9ANPC1TP53POLB | |
| SCHEMBL8254073 | 0.80 | ALDH1A1 (0.74) | ALDH1A1RAB9ANPC1TP53POLB | |
| SCHEMBL20684919 | 0.80 | SIGMAR1 (0.59) | ALDH1A1KDM4EMEN1KMT2ANCF1 | |
| SCHEMBL21238989 | 0.80 | POLB (0.66) | ALDH1A1POLBSMN1; SMN2TSHRKDM4E | |
| SCHEMBL5095148 | 0.80 | HRH3 (0.65) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19391016 | 0.80 | NCF1 (0.44) | ALDH1A1RAB9ANPC1TP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2018-03-21 | — | — | EP | disclosed |