Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1998051 | 0.85 | MAPT (0.35) | MAPTL3MBTL1SMN1; SMN2NPC1MAPK1 | |
| SCHEMBL2003305 | 0.85 | MAPT (0.34) | TGFBR1MAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL2006339 | 0.79 | LMNA (0.44) | TGFBR1MAPTPDE3BPDE3AALDH1A1 | |
| SCHEMBL2001550 | 0.77 | MAPT (0.37) | TGFBR1MAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL2000118 | 0.73 | KCNH2 (0.33) | TGFBR1MAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL2007396 | 0.71 | ADORA2A (0.35) | TGFBR1MAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL2001837 | 0.69 | LMNA (0.43) | MAPTL3MBTL1ALDH1A1LMNAHTT | |
| SCHEMBL1998048 | 0.69 | MAPT (0.36) | TGFBR1MAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL5745204 | 0.68 | LMNA (0.36) | TGFBR1MAPTMAPK1PIK3CAPIK3R1 | |
| SCHEMBL2761238 | 0.68 | LMNA (0.51) | MAPTMAPK1ALDH1A1LMNAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960413-B2 | Pyrazole compounds | MERCK PATENT GMBH (DE) | 2011-06-14 | — | — | US | disclosed |
| US-20060276650-A1 | Pyrazole compounds | MERCK PATENT GMBH (DE) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276650-A1 | Pyrazole compounds | HTR1D, HTR1A, HTR3A | TGFBR1 1021/4885FGFR2 3595/4885MAPT 2121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.