Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2001550 | 0.92 | MAPT (0.37) | LMNAMAPTGAAHRH3ALDH1A1 | |
| SCHEMBL2001837 | 0.91 | LMNA (0.43) | LMNAMAPTGAAHRH3ALDH1A1 | |
| SCHEMBL2761238 | 0.90 | LMNA (0.51) | LMNAMAPTGAAHRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1997591 | 0.89 | LMNA (0.50) | LMNAMAPTGAAHRH3ALDH1A1 | |
| SCHEMBL1999587 | 0.86 | LMNA (0.44) | LMNAMAPTGAAHRH3ALDH1A1 | |
| SCHEMBL1998528 | 0.85 | LMNA (0.42) | LMNAMAPTGAAHRH3ALDH1A1 | |
| SCHEMBL2000118 | 0.85 | KCNH2 (0.33) | LMNAMAPTGAAALDH1A1PDE3B | |
| SCHEMBL5745204 | 0.84 | LMNA (0.36) | LMNAMAPTGAAHRH3ALDH1A1 | |
| SCHEMBL1998216 | 0.83 | LMNA (0.42) | LMNAMAPTGAAHRH3ALDH1A1 | |
| SCHEMBL2000031 | 0.82 | MAPT (0.35) | LMNAMAPTGAAHRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960413-B2 | Pyrazole compounds | MERCK PATENT GMBH (DE) | 2011-06-14 | — | — | US | disclosed |
| US-20060276650-A1 | Pyrazole compounds | MERCK PATENT GMBH (DE) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276650-A1 | Pyrazole compounds | HTR1D, HTR1A, HTR3A | LMNA 3297/4885MAPT 2121/4885GAA 4616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.