Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 6/20 | 0.39 |
| ▸ | MMP9 | P14780 | 6/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 3/20 | 0.39 |
| ▸ | MMP13 | P45452 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18109314 | 0.99 | MMP2 (0.37) | MMP2MMP9MMP3MEN1KMT2A | |
| SCHEMBL18109699 | 0.95 | SLC10A2 (0.38) | MMP2MMP9MMP3MEN1KMT2A | |
| SCHEMBL19940946 | 0.90 | KDM1A (0.37) | MEN1KMT2ASMN1; SMN2LMNASLC10A2 | |
| SCHEMBL485258 | 0.84 | LMNA (0.38) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4337211 | 0.81 | LMNA (0.33) | MEN1KMT2ALMNA | |
| SCHEMBL4330497 | 0.81 | CYP19A1 (0.33) | SMN1; SMN2LMNACYP19A1 | |
| SCHEMBL5807914 | 0.81 | CYP19A1 (0.33) | SMN1; SMN2LMNACYP19A1 | |
| SCHEMBL25193093 | 0.79 | SLC10A2 (0.40) | MEN1KMT2AALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL4336144 | 0.79 | LMNA (0.34) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4339935 | 0.78 | TDP1 (0.35) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3507288-B1 | 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE DERIVATIES AS TOLL LIKE RECEPTOR MODULATORS | GILEAD SCIENCES INC (US) | 2020-08-26 | — | — | EP | disclosed |
| US-10640499-B2 | Toll like receptor modulator compounds | GILEAD SCIENCES, INC. (US) | 2020-05-05 | — | — | US | disclosed |
| US-20180086755-A1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10640499-B2 | Toll like receptor modulator compounds | TLR8, TLR3, TLR6 | MMP2 2544/4885MMP9 1457/4885MMP3 2082/4885 |
| US-20180086755-A1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | TLR8, TLR3, TLR6 | MMP2 2680/4885MMP9 1635/4885MMP3 2172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.