Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 2/20 | 0.36 |
| ▸ | PRKACG | P22612 | 2/20 | 0.36 |
| ▸ | PRKACB | P22694 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19993620 | 0.85 | ADORA2A (0.38) | PLA2G2AMAPTADORA1ADORA2AADORA2B | |
| SCHEMBL19993793 | 0.79 | PRKACA (0.34) | PLA2G2AMAPTADORA1ADORA2AADORA2B | |
| SCHEMBL19993573 | 0.79 | KDM4E (0.37) | PLA2G2AMAPTGAAADORA1ADORA2A | |
| SCHEMBL19993560 | 0.77 | GAA (0.47) | MAPTGAAFGFR1FGFR4FGFR2 | |
| SCHEMBL30515932 | 0.75 | FGFR2 (0.35) | MAPTGAAFGFR1FGFR4FGFR2 | |
| SCHEMBL15345676 | 0.72 | FGFR2 (0.47) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL19993795 | 0.72 | TP53 (0.35) | MAPTFGFR1FGFR4ALDH1A1PRKACA | |
| SCHEMBL29829257 | 0.71 | FGFR2 (0.38) | FGFR1FGFR4ALDH1A1FGFR2FGFR3 | |
| SCHEMBL1847850 | 0.70 | PRKACA (0.48) | PLA2G2AGAAPRKACAPRKACGPRKACB | |
| SCHEMBL674040 | 0.70 | ALDH1A1 (0.65) | MAPTGAAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049781-A1 | ALKYNYL-SUBSTITUTED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京天诚医药科技有限公司 | 2018-03-22 | — | — | WO | disclosed |