Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29829307 | 0.81 | ALDH1A1 (0.38) | FGFR2FGFR3GRM5ALDH1A1FGFR1 | |
| SCHEMBL29828922 | 0.80 | GRM5 (0.37) | FGFR2FGFR3GRM5ALDH1A1FGFR1 | |
| SCHEMBL674040 | 0.75 | ALDH1A1 (0.65) | GRM5ALDH1A1 | |
| SCHEMBL29828921 | 0.74 | FGFR1 (0.44) | FGFR2FGFR3FGFR1FGFR4 | |
| SCHEMBL29724132 | 0.74 | GRM5 (0.38) | FGFR2FGFR3GRM5HPGDSFGFR4 | |
| SCHEMBL202404 | 0.73 | ALDH1A1 (0.61) | GRM5ALDH1A1HPGDSKDM1A | |
| SCHEMBL509576 | 0.71 | ALDH1A1 (0.58) | GRM5ALDH1A1HPGDSKDM1A | |
| SCHEMBL29829575 | 0.71 | GRM5 (0.51) | FGFR2FGFR3GRM5ALDH1A1FGFR1 | |
| SCHEMBL19993623 | 0.71 | PLA2G2A (0.44) | FGFR2FGFR3ALDH1A1FGFR1FGFR4 | |
| SCHEMBL29141348 | 0.69 | APP (0.48) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114853739-B | Acetylenic pyrazine FGFR inhibitor and preparation method and application thereof | 药雅科技(上海)有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-114853739-A | Alkynyl pyrazine FGFR inhibitor and preparation method and application thereof | 药雅科技(上海)有限公司 | 2022-08-05 | — | — | CN | disclosed |