Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16874602 | 0.82 | MEN1 (0.63) | SIGMAR1SLC18A3MEN1KMT2AACHE | |
| SCHEMBL6042122 | 0.82 | MEN1 (0.63) | SIGMAR1SLC18A3MEN1KMT2AACHE | |
| SCHEMBL16874797 | 0.82 | MEN1 (0.63) | SIGMAR1SLC18A3MEN1KMT2AACHE | |
| SCHEMBL3488099 | 0.81 | BCHE (0.47) | SIGMAR1MEN1KMT2ACHRM2CHRM3 | |
| SCHEMBL19972380 | 0.80 | SIGMAR1 (0.57) | SIGMAR1SLC18A3MEN1KMT2AMCHR1 | |
| SCHEMBL28667637 | 0.79 | ACHE (0.49) | SIGMAR1MCHR1ACHE | |
| SCHEMBL28453656 | 0.79 | ACHE (0.49) | SIGMAR1MCHR1ACHE | |
| Hydrochloric Acid SCHEMBL28649444 | 0.78 | ACHE (0.48) | SIGMAR1MCHR1ACHE | |
| SCHEMBL6360566 | 0.76 | SIGMAR1 (0.63) | SIGMAR1MEN1KMT2ACHRM4ACHE | |
| SCHEMBL6046424 | 0.76 | REN (0.49) | SIGMAR1MEN1KMT2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515902-A1 | 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL | Grünenthal GmbH (DE) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018054549-A1 | 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL | Grünenthal GmbH (DE) | 2018-03-29 | — | — | WO | disclosed |