Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.54 |
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16032659 | 0.90 | SIGMAR1 (0.52) | SIGMAR1MCHR1FAAHACHECHRM4 | |
| SCHEMBL16032661 | 0.90 | SIGMAR1 (0.52) | SIGMAR1MCHR1FAAHACHECHRM4 | |
| SCHEMBL16032662 | 0.90 | SIGMAR1 (0.52) | SIGMAR1MCHR1FAAHACHECHRM4 | |
| SCHEMBL19972280 | 0.83 | MCHR1 (0.56) | SIGMAR1MCHR1DRD2DRD4 | |
| SCHEMBL16874797 | 0.83 | MEN1 (0.63) | SIGMAR1ACHESLC18A3MEN1KMT2A | |
| SCHEMBL16874602 | 0.83 | MEN1 (0.63) | SIGMAR1ACHESLC18A3MEN1KMT2A | |
| SCHEMBL6042122 | 0.83 | MEN1 (0.63) | SIGMAR1ACHESLC18A3MEN1KMT2A | |
| SCHEMBL19972384 | 0.82 | FPR1 (0.55) | KMT2A | |
| SCHEMBL19994149 | 0.80 | SIGMAR1 (0.51) | SIGMAR1MCHR1FAAHACHECHRM4 | |
| SCHEMBL19972322 | 0.78 | FPR1 (0.67) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515902-A1 | 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL | Grünenthal GmbH (DE) | 2019-07-31 | — | — | EP | disclosed |
| US-10265310-B2 | 6-membered cyclic amines or lactames substituted with urea and phenyl | Grünenthal GmbH (DE) | 2019-04-23 | — | — | US | disclosed |
| WO-2018054549-A1 | 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL | Grünenthal GmbH (DE) | 2018-03-29 | — | — | WO | disclosed |
| US-20180078541-A1 | 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL | Grünenthal GmbH (DE) | 2018-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180078541-A1 | 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL | FPR2, FPR1, FPR3 | SIGMAR1 620/4885MCHR1 1889/4885FAAH 218/4885 |
| US-10265310-B2 | 6-membered cyclic amines or lactames substituted with urea and phenyl | FPR2, FPR1, FPR3 | SIGMAR1 620/4885MCHR1 1889/4885FAAH 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.