Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.61 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.61 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.55 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.52 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | RHEB | Q15382 | 1/20 | 0.51 |
| ▸ | TOP1 | P11387 | 2/20 | 0.48 |
| ▸ | TOP2A | P11388 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30343735 | 0.90 | RHEB (0.51) | PKN1PKN2NPBWR1CHEK2SIRT2 | |
| SCHEMBL19994743 | 0.90 | RHEB (0.51) | PKN1PKN2NPBWR1CHEK2SIRT2 | |
| SCHEMBL20982510 | 0.84 | PKN1 (0.82) | PKN1PKN2CHEK2DGAT1SOAT1 | |
| SCHEMBL20001657 | 0.80 | RHEB (0.50) | PKN1PKN2CHEK2SIRT2SIRT1 | |
| SCHEMBL30343715 | 0.80 | RHEB (0.50) | PKN1PKN2CHEK2SIRT2SIRT1 | |
| SCHEMBL19175759 | 0.78 | DGAT1 (0.77) | NPBWR1SIRT2SIRT1DGAT1SOAT1 | |
| SCHEMBL3341423 | 0.78 | PKN1 (0.72) | PKN1PKN2NPBWR1CHEK2DGAT1 | |
| SCHEMBL14816640 | 0.78 | PKN1 (0.72) | PKN1PKN2CHEK2SIRT2DGAT1 | |
| SCHEMBL18764054 | 0.77 | CHEK2 (0.78) | PKN1PKN2NPBWR1CHEK2DGAT1 | |
| SCHEMBL902210 | 0.77 | PKN1 (0.60) | PKN1PKN2CHEK2DGAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515904-A1 | BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS | Centre Leon Berard (FR) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018054989-A1 | BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS | CENTRE LEON BERARD (FR) | 2018-03-29 | — | — | WO | disclosed |