Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.60 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.56 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.54 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.54 |
| ▸ | FASN | P49327 | 4/20 | 0.50 |
| ▸ | RHEB | Q15382 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12474232 | 0.89 | PKN1 (0.58) | PKN1PKN2CHEK2DGAT1SOAT1 | |
| SCHEMBL20982510 | 0.83 | PKN1 (0.82) | PKN1PKN2CHEK2DGAT1SOAT1 | |
| SCHEMBL901002 | 0.82 | DGAT1 (0.74) | PKN1PKN2CHEK2DGAT1SOAT1 | |
| SCHEMBL902654 | 0.79 | FASN (0.40) | PKN1PKN2DGAT1SOAT1KCNH2 | |
| SCHEMBL19994744 | 0.77 | PKN1 (0.61) | PKN1PKN2CHEK2DGAT1SOAT1 | |
| SCHEMBL14816640 | 0.77 | PKN1 (0.72) | PKN1PKN2CHEK2DGAT1SOAT1 | |
| SCHEMBL3341423 | 0.77 | PKN1 (0.72) | PKN1PKN2CHEK2DGAT1SOAT1 | |
| SCHEMBL18764054 | 0.76 | CHEK2 (0.78) | PKN1PKN2CHEK2DGAT1SOAT1 | |
| SCHEMBL11567128 | 0.76 | HRH3 (0.52) | KCNH2 | |
| SCHEMBL23563056 | 0.75 | PKN1 (0.68) | PKN1PKN2CHEK2DGAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |