Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PORCN | Q9H237 | 4/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21935695 | 0.89 | PORCN (0.46) | PORCNTRPA1TRPV4TP53RXFP1 | |
| SCHEMBL21935443 | 0.84 | PORCN (0.40) | PORCNTRPA1TRPV4TP53RXFP1 | |
| SCHEMBL20029975 | 0.82 | MEN1 (0.48) | TRPA1TP53RXFP1MAPTSMN1; SMN2 | |
| SCHEMBL19626637 | 0.82 | PORCN (0.51) | PORCN | |
| SCHEMBL19626686 | 0.82 | RAB9A (0.52) | TRPA1TRPV4TP53RXFP1MAPT | |
| SCHEMBL22105263 | 0.81 | PORCN (0.40) | PORCNTRPA1TRPV4TP53MGLL | |
| SCHEMBL19626687 | 0.80 | SMN1; SMN2 (0.42) | RXFP1MGLLMAPTSMN1; SMN2MEN1 | |
| SCHEMBL19590943 | 0.80 | GAA (0.45) | CASP7SMN1; SMN2LMNAGAAALDH1A1 | |
| SCHEMBL19590905 | 0.80 | TRPA1 (0.41) | PORCNTRPA1TRPV4TP53RXFP1 | |
| SCHEMBL22105261 | 0.80 | PSEN1 (0.41) | PORCNRXFP1MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926320-B2 | Purine diones as Wnt pathway modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-03-27 | — | — | US | disclosed |