Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | BLM | P54132 | 2/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | MPO | P05164 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.59 |
| ▸ | APAF1 | O14727 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ECE1 | P42892 | 5/20 | 0.52 |
| ▸ | IL1RN | P18510 | 3/20 | 0.51 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL22500851 | 1.00 | KDM4E (0.70) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL7855013 | 1.00 | KDM4E (0.70) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL4294273 | 0.94 | KDM4E (0.61) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL27689262 | 0.93 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL2005670 | 0.92 | KDM4E (0.82) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL6688035 | 0.92 | KDM4E (0.82) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL531051 | 0.92 | KDM4E (0.82) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL2143522 | 0.92 | KDM4E (0.82) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL8059982 | 0.92 | KDM4E (0.82) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL27153460 | 0.92 | KDM4E (0.82) | KDM4EMAPTLMNATSHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100818-B1 | INHIBITORS OF HIV MEMBRANE FUSION | WHITEHEAD BIOMEDICAL INST (US) | 2013-01-02 | — | — | EP | disclosed |
| US-7960504-B2 | Inhibitors of HIV membrane fusion | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2011-06-14 | — | — | US | disclosed |
| US-20050221294-A1 | Inhibitors of HIV membrane fusion | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2005-10-06 | — | — | US | disclosed |
| US-6841657-B2 | Inhibitors of HIV membrane fusion | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2005-01-11 | — | — | US | disclosed |
| US-6818740-B1 | FOR DRUG SCREENING POLYMERASE/PROTEASE INHIBITORS; ENVELOPE PROTEINS | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH | 2004-11-16 | — | — | US | disclosed |
| US-20020077284-A1 | Inhibitors of HIV membrane fusion | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2002-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020077284-A1 | Inhibitors of HIV membrane fusion | CD4, NSF, CYTH3 | KDM4E 4215/4885MAPT 935/4885LMNA 1428/4885 |
| US-20050221294-A1 | Inhibitors of HIV membrane fusion | CD4, NSF, CYTH3 | KDM4E 4215/4885MAPT 935/4885LMNA 1428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.