Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | MPO | P05164 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.54 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | IL1RN | P18510 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL2000070 | 0.94 | KDM4E (0.70) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL7855013 | 0.94 | KDM4E (0.70) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL22500851 | 0.94 | KDM4E (0.70) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28790481 | 0.91 | KDM4E (0.74) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28171407 | 0.91 | KDM4E (0.74) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL4287329 | 0.88 | KDM4E (0.80) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL3442897 | 0.87 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL27689262 | 0.87 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL5314267 | 0.87 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL8059982 | 0.87 | KDM4E (0.82) | KDM4EMAPTLMNATSHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090220997-A1 | Stimulating G Protein-Coupled Receptors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2009-09-03 | — | — | US | disclosed |
| WO-2007033233-A2 | STIMULATING G PROTEIN-COUPLED RECEPTORS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2007-03-22 | — | — | WO | disclosed |