Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | S100A4 | P26447 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3071233 | 0.84 | TDP1 (0.61) | TDP1GPR35ALDH1A1MEN1KMT2A | |
| SCHEMBL2002908 | 0.83 | PIN1 (0.45) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL41402 | 0.81 | TSHR (0.59) | TDP1HPGDGPR35ALDH1A1MEN1 | |
| SCHEMBL29763129 | 0.81 | TSHR (0.59) | TDP1HPGDGPR35ALDH1A1MEN1 | |
| Ammonia Solution, Strong SCHEMBL28163519 | 0.79 | TSHR (0.57) | TDP1HPGDGPR35ALDH1A1MEN1 | |
| SCHEMBL1970696 | 0.78 | TDP1 (0.54) | TDP1GPR35ALDH1A1MEN1KMT2A | |
| SCHEMBL28282595 | 0.78 | TDP1 (0.65) | TDP1HPGDGPR35ALDH1A1MEN1 | |
| SCHEMBL29460277 | 0.78 | TDP1 (0.65) | TDP1HPGDGPR35ALDH1A1MEN1 | |
| SCHEMBL58157 | 0.78 | TDP1 (0.65) | TDP1HPGDGPR35ALDH1A1MEN1 | |
| SCHEMBL78743 | 0.78 | HPGD (0.62) | TDP1HPGDGPR35ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4744661-A2 | NOVEL PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2026-05-20 | — | — | EP | disclosed |
| EP-4298092-B1 | NOVEL PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2025-11-26 | — | — | EP | disclosed |
| US-20240025883-A1 | PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-01-25 | — | — | US | disclosed |
| EP-4298092-A1 | NOVEL PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2024-01-03 | — | — | EP | disclosed |
| CN-116829550-A | Pyrimidine-2-ylsulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |
| WO-2022180136-A1 | NOVEL PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2022-09-01 | — | — | WO | disclosed |
| US-7960408-B2 | Quinolinyl and benzothiazolyl modulators | AMGEN INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-7960408-B2 | Quinolinyl and benzothiazolyl modulators | AMGEN INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-7960408-B2 | Quinolinyl and benzothiazolyl modulators | AMGEN INC. (US) | 2011-06-14 | — | — | US | disclosed |
| WO-2010116270-A1 | EP2/4 AGONISTS | PFIZER INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| CN-85108458-B | Novel 9-chloro-1, 5-benzothiazepine derivatives and process for producing the same | 田道制药株式会社 | 1988-05-25 | — | — | CN | disclosed |
| US-4665068-A | HYPOTENSIVES, VASODILATORS | TANABE SEIYAKU CO., LTD. (JP) | 1987-05-12 | — | — | US | disclosed |
| CN-85108458-A | New 9-chloro-1,5-benzo thiophene is at product derivative and preparation method thereof | — | 1986-07-30 | — | — | CN | disclosed |
| EP-0182273-A1 | 1,5-Benzothiazepine derivatives, a process for preparing the same, pharmaceutical compositions as well as the use thereof | Tanabe Seiyaku Co., Ltd. (JP) | 1986-05-28 | — | — | EP | disclosed |
| US-4585768-A | ANTICOAGULANTS | TANABE SEIYAKU CO., LTD. (JP) | 1986-04-29 | — | — | US | disclosed |
| EP-0158339-A2 | 1,5-Benzothiazephine derivatives, processes for preparing the same and pharmaceutical compositions | Tanabe Seiyaku Co., Ltd. (JP) | 1985-10-16 | — | — | EP | disclosed |
| EP-0039440-B1 | MEDICINES CONTAINING SUBSTITUTED BENZOTHIAZOL-2-(3H)-ONES | Dr. Karl Thomae GmbH (DE) | 1983-06-22 | — | — | EP | disclosed |
| EP-0025528-A1 | 1-(2-Acetylphenylthio)-3-alkylamino-2-propanols and their acid-addition salts, process for their preparation and medicines containing them | A. Nattermann & Cie. GmbH (DE) | 1981-03-25 | — | — | EP | disclosed |
| EP-0025274-A1 | Preparation of aminosulphonic acids and their derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-03-18 | — | — | EP | disclosed |
| US-4066641-A | METHOD FOR CYCLIZATION TO GIVE CEPHEM RING | HAMASHIMA YOSHIO | 1978-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025883-A1 | PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | GPR17, GPR27, GPR119 | TDP1 3673/4885HPGD 1638/4885GPR35 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.