Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002706 | 1.00 | HSD11B1 (0.47) | HSD11B1L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL20002685 | 0.89 | HSD11B1 (0.41) | HSD11B1L3MBTL1ALDH1A1RORC | |
| SCHEMBL20002751 | 0.89 | NOTUM (0.42) | L3MBTL1RORC | |
| SCHEMBL20002641 | 0.89 | TDP1 (0.42) | HSD11B1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20002564 | 0.88 | NAMPT (0.41) | HSD11B1L3MBTL1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20002400 | 0.88 | TACR3 (0.42) | HSD11B1L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL20002286 | 0.88 | TACR1 (0.45) | RORC | |
| SCHEMBL20002574 | 0.88 | ALDH1A1 (0.51) | L3MBTL1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20002705 | 0.88 | ALDH1A1 (0.41) | HSD11B1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20003089 | 0.88 | GPR183 (0.45) | HSD11B1MEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |