Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002286 | 0.91 | TACR1 (0.45) | — | |
| SCHEMBL20002706 | 0.88 | HSD11B1 (0.47) | L3MBTL1ALDH1A1HSD11B1KMT2ASMN1; SMN2 | |
| SCHEMBL20002698 | 0.88 | HSD11B1 (0.47) | L3MBTL1ALDH1A1HSD11B1KMT2ASMN1; SMN2 | |
| SCHEMBL20002340 | 0.87 | TACR3 (0.39) | L3MBTL1CYP46A1ALDH1A1 | |
| SCHEMBL22662762 | 0.87 | SLC6A9 (0.43) | — | |
| SCHEMBL20002685 | 0.87 | HSD11B1 (0.41) | L3MBTL1CYP46A1ALDH1A1HSD11B1 | |
| SCHEMBL20002751 | 0.87 | NOTUM (0.42) | L3MBTL1 | |
| SCHEMBL20002854 | 0.86 | RORC (0.42) | L3MBTL1CYP46A1ALDH1A1HSD11B1LMNA | |
| SCHEMBL20002400 | 0.86 | TACR3 (0.42) | L3MBTL1ALDH1A1HSD11B1KMT2ASMN1; SMN2 | |
| SCHEMBL20002863 | 0.85 | L3MBTL1 (0.39) | L3MBTL1CYP46A1ALDH1A1HSD11B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |