Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 13/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.31 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.30 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.30 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.30 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18799682 | 0.85 | RORC (0.40) | RORC | |
| SCHEMBL16886258 | 0.85 | RORC (0.35) | RORCHSD11B1PDK1PDK2PDK3 | |
| SCHEMBL20003145 | 0.85 | RORC (0.35) | RORCHSD11B1PDK1PDK2PDK3 | |
| SCHEMBL16892227 | 0.81 | SMN1; SMN2 (0.35) | RORCNR3C2NR3C1 | |
| SCHEMBL20002774 | 0.80 | ACHE (0.36) | RORC | |
| SCHEMBL16886260 | 0.79 | RORC (0.39) | RORC | |
| SCHEMBL20002812 | 0.78 | TAAR1 (0.46) | — | |
| SCHEMBL20002194 | 0.77 | KDM1A (0.39) | RORCNR3C2NR3C1 | |
| SCHEMBL20001981 | 0.75 | RORC (0.37) | RORCPDK1PDK2PDK3PDK4 | |
| SCHEMBL18214991 | 0.72 | RORC (0.40) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |