Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 16/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | GPR6 | P46095 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002866 | 0.89 | RORC (0.49) | RORCGPR6 | |
| SCHEMBL20002497 | 0.88 | RORC (0.44) | RORCNR1I2CCR5CYP11B1CYP11B2 | |
| SCHEMBL20002880 | 0.84 | RORC (0.46) | RORCNR1I2CCR5CYP11B1CYP11B2 | |
| SCHEMBL20002922 | 0.84 | RORC (0.46) | RORCNR1I2CCR5CYP11B1CYP11B2 | |
| SCHEMBL20003053 | 0.82 | CCR5 (0.46) | RORCNR1I2CCR5CYP11B1CYP11B2 | |
| SCHEMBL20002321 | 0.82 | CCR5 (0.46) | RORCNR1I2CCR5CYP11B1CYP11B2 | |
| SCHEMBL20002251 | 0.81 | RORC (0.52) | RORCNR1I2CCR5CYP11B1CYP11B2 | |
| SCHEMBL20002406 | 0.78 | RORC (0.42) | RORCCCR5 | |
| SCHEMBL20002869 | 0.77 | RORC (0.44) | RORCCCR5 | |
| SCHEMBL14413535 | 0.77 | EPHX2 (0.47) | RORCCCR5GPR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |