Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 10/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002171 | 0.90 | KMT2A (0.38) | RORCMAPK1 | |
| SCHEMBL20002445 | 0.86 | RORC (0.41) | RORCKCNH2MAPK1 | |
| SCHEMBL20002207 | 0.85 | RORC (0.45) | RORCNR1I2 | |
| SCHEMBL20002924 | 0.84 | MAPK1 (0.34) | RORCMAPK1 | |
| SCHEMBL20002280 | 0.83 | TACR1 (0.40) | RORCNR1I2HDAC3HDAC1HDAC2 | |
| SCHEMBL20002856 | 0.83 | RORC (0.42) | RORCDPP4DPP7 | |
| SCHEMBL20002286 | 0.82 | TACR1 (0.45) | RORCNR1I2HDAC3HDAC1HDAC2 | |
| SCHEMBL20003044 | 0.81 | RORC (0.40) | RORC | |
| SCHEMBL20003029 | 0.80 | RORC (0.41) | RORCMAPK1 | |
| SCHEMBL20003241 | 0.79 | RORC (0.41) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |