Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | FASN | P49327 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002926 | 0.90 | RORC (0.43) | RORCMAPK1 | |
| SCHEMBL20002445 | 0.87 | RORC (0.41) | RORCNPC1RAB9AATMFAAH | |
| SCHEMBL20002207 | 0.86 | RORC (0.45) | RORCNPC1RAB9AATMMAPT | |
| SCHEMBL20002924 | 0.85 | MAPK1 (0.34) | RORCNPC1RAB9AATMFASN | |
| SCHEMBL20002499 | 0.84 | HSD11B1 (0.45) | KMT2AOPRM1HSD11B1 | |
| SCHEMBL20002167 | 0.81 | KDM1A (0.40) | RORCNPC1RAB9AKDM1AMAOB | |
| SCHEMBL20002564 | 0.81 | NAMPT (0.41) | KMT2ALMNAHSD11B1SMN1; SMN2 | |
| SCHEMBL20003044 | 0.80 | RORC (0.40) | RORCNPC1RAB9AATMMAPT | |
| SCHEMBL20002856 | 0.79 | RORC (0.42) | KMT2ARORCNPC1RAB9AATM | |
| SCHEMBL20003029 | 0.79 | RORC (0.41) | RORCKDM1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |