Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 3/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003241 | 0.90 | RORC (0.41) | RORCHSD11B1LMNAKMT2ANPC1 | |
| SCHEMBL20002796 | 0.86 | RORC (0.45) | RORCNPC1RAB9AALDH1A1HTT | |
| SCHEMBL20003044 | 0.85 | RORC (0.40) | RORCNPC1RAB9AALDH1A1HTT | |
| SCHEMBL20002926 | 0.83 | RORC (0.43) | RORCDPP4DPP7 | |
| SCHEMBL20002171 | 0.79 | KMT2A (0.38) | RORCHSD11B1LMNAKMT2ANPC1 | |
| SCHEMBL20002280 | 0.78 | TACR1 (0.40) | RORCHSD11B1DPP4DPP7 | |
| SCHEMBL20003052 | 0.77 | HSD11B1 (0.38) | RORCHSD11B1KMT2ANPC1RAB9A | |
| SCHEMBL20002748 | 0.77 | RORC (0.39) | RORCHSD11B1LMNAKMT2ANPC1 | |
| SCHEMBL20002286 | 0.77 | TACR1 (0.45) | RORC | |
| SCHEMBL20002445 | 0.77 | RORC (0.41) | RORCHSD11B1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |