Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 10/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003180 | 0.83 | RORC (0.54) | RORC | |
| SCHEMBL20002703 | 0.78 | ALDH1A1 (0.46) | RORCHSD11B1 | |
| SCHEMBL20002822 | 0.73 | RORC (0.58) | RORC | |
| SCHEMBL20002497 | 0.71 | RORC (0.44) | RORC | |
| SCHEMBL11995531 | 0.71 | TDP1 (0.40) | MAPTHSD11B1 | |
| SCHEMBL20002828 | 0.71 | RORC (0.54) | RORC | |
| SCHEMBL18711258 | 0.70 | MEN1 (0.50) | RORCNAMPTSPR | |
| SCHEMBL20002406 | 0.70 | RORC (0.42) | RORCMAPTNAMPT | |
| SCHEMBL20002927 | 0.69 | ALDH1A1 (0.46) | RORCHSD11B1 | |
| SCHEMBL20003055 | 0.68 | RORC (0.42) | RORCMAPTHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |