Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 17/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003236 | 0.83 | RORC (0.45) | RORC | |
| SCHEMBL20002822 | 0.83 | RORC (0.58) | RORC | |
| SCHEMBL20003061 | 0.79 | RORC (0.54) | RORC | |
| SCHEMBL20002927 | 0.78 | ALDH1A1 (0.46) | RORC | |
| SCHEMBL20002976 | 0.76 | RORC (0.43) | RORC | |
| SCHEMBL20003009 | 0.72 | RORC (0.54) | RORC | |
| SCHEMBL20002828 | 0.71 | RORC (0.54) | RORC | |
| SCHEMBL20003055 | 0.70 | RORC (0.42) | RORC | |
| SCHEMBL16886734 | 0.70 | RORC (1.00) | RORC | |
| SCHEMBL20002767 | 0.70 | RORC (0.43) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |