Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 8/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2001878 | 0.93 | ALOX5AP (0.42) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL2004225 | 0.93 | PLA2G2A (0.45) | ALOX5APALOX5PTGS2PLA2G2ACYP3A4 | |
| SCHEMBL2002959 | 0.93 | ALOX5AP (0.42) | ALOX5APALOX5PTGS1PTGS2CYP3A4 | |
| SCHEMBL2006766 | 0.91 | F2RL3 (0.40) | ALOX5APCYP3A4CYP2C9NTRK1 | |
| SCHEMBL2002560 | 0.90 | MAPT (0.40) | ALOX5APCYP3A4 | |
| SCHEMBL2008081 | 0.90 | FAAH (0.41) | ALOX5APALOX5CYP3A4CYP2C9 | |
| SCHEMBL2008374 | 0.90 | ALOX5AP (0.44) | ALOX5APALOX5PTGS1PTGS2PLA2G2A | |
| SCHEMBL2001077 | 0.89 | PTGES2 (0.41) | ALOX5AP | |
| SCHEMBL1999580 | 0.88 | MAPT (0.39) | ALOX5APALOX5 | |
| SCHEMBL2004616 | 0.88 | ALOX5AP (0.42) | ALOX5APALOX5PTGS1PTGS2PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |