Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.38 |
| ▸ | PTGES | O14684 | 2/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002560 | 0.94 | MAPT (0.40) | MAPTFAAHMEN1KMT2APTGES2 | |
| SCHEMBL2002457 | 0.92 | ALOX5 (0.36) | MAPTPKMGAAALDH1A1KDM4E | |
| SCHEMBL2008949 | 0.92 | PTGES2 (0.41) | MAPTPKMGAAALDH1A1FAAH | |
| SCHEMBL2001077 | 0.91 | PTGES2 (0.41) | FAAHMEN1KMT2APTGES2PTGES | |
| SCHEMBL2003933 | 0.90 | ALDH1A1 (0.41) | ALDH1A1FAAHKDM4ELMNAMEN1 | |
| SCHEMBL2002966 | 0.90 | L3MBTL1 (0.40) | MAPTPKMGAAALDH1A1FAAH | |
| SCHEMBL2001846 | 0.89 | FAAH (0.41) | FAAH | |
| SCHEMBL2004508 | 0.89 | MAPT (0.42) | MAPTPKMGAAALDH1A1FAAH | |
| SCHEMBL2004225 | 0.89 | PLA2G2A (0.45) | MAPTPKMALDH1A1FAAHLMNA | |
| SCHEMBL2000328 | 0.88 | ALOX5AP (0.43) | ALOX5APALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |