Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.41 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006132 | 0.92 | ALOX5AP (0.43) | ALOX5APALOX5SLC26A4KMT2ANTRK1 | |
| SCHEMBL2003596 | 0.92 | PLA2G2A (0.48) | ALOX5APPLA2G2AKMT2AALDH1A1MAPK1 | |
| SCHEMBL2005691 | 0.92 | ALOX5AP (0.43) | ALOX5APALOX5KMT2ANTRK1PTGS1 | |
| SCHEMBL2003998 | 0.90 | SLC26A4 (0.40) | ALOX5APSLC26A4NTRK1KDM4EALDH1A1 | |
| SCHEMBL2000328 | 0.90 | ALOX5AP (0.43) | ALOX5APALOX5PLA2G2ANTRK1PTGS1 | |
| SCHEMBL2005326 | 0.89 | MEN1 (0.43) | ALOX5APKMT2AKDM4EALDH1A1RECQL | |
| SCHEMBL2000884 | 0.89 | FAAH (0.44) | — | |
| SCHEMBL2001701 | 0.88 | MEN1 (0.42) | ALOX5APALOX5KMT2A | |
| SCHEMBL2004508 | 0.87 | MAPT (0.42) | ALOX5APPLA2G2AKMT2AKDM4EALDH1A1 | |
| SCHEMBL2003946 | 0.86 | ALOX5AP (0.42) | ALOX5APALOX5PLA2G2AKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |