Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.49 |
| ▸ | KDR | P35968 | 8/20 | 0.49 |
| ▸ | AXL | P30530 | 5/20 | 0.49 |
| ▸ | MERTK | Q12866 | 3/20 | 0.47 |
| ▸ | RET | P07949 | 4/20 | 0.43 |
| ▸ | KIT | P10721 | 4/20 | 0.43 |
| ▸ | FLT3 | P36888 | 4/20 | 0.43 |
| ▸ | FLT1 | P17948 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | LYN | P07948 | 2/20 | 0.43 |
| ▸ | HCK | P08631 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003745 | 0.87 | MET (0.40) | METKDRAXL | |
| SCHEMBL20003725 | 0.87 | MET (0.55) | METKDRAXLMERTKRET | |
| SCHEMBL20003880 | 0.80 | MET (0.58) | METKDRAXLMERTKRET | |
| SCHEMBL20003754 | 0.78 | MET (0.59) | METKDRAXLMERTKRET | |
| SCHEMBL20003636 | 0.77 | MET (0.56) | METKDRAXLMERTKRET | |
| SCHEMBL20003626 | 0.77 | MET (0.56) | METKDRAXLMERTKRET | |
| SCHEMBL22643607 | 0.77 | HTR1A (0.42) | METKDRAXLFLT1EGFR | |
| SCHEMBL20003858 | 0.76 | MET (0.62) | METKDRAXLMERTKRET | |
| SCHEMBL20003729 | 0.75 | MET (0.57) | METKDRAXLMERTKRET | |
| SCHEMBL20003965 | 0.75 | MET (0.59) | METKDRAXLMERTKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299369-A1 | PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2018-03-28 | — | — | EP | disclosed |