Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.53 |
| ▸ | MC1R | Q01726 | 2/20 | 0.53 |
| ▸ | MC3R | P41968 | 1/20 | 0.52 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.52 |
| ▸ | KLK7 | P49862 | 2/20 | 0.52 |
| ▸ | GLP1R | P43220 | 6/20 | 0.51 |
| ▸ | GCGR | P47871 | 2/20 | 0.51 |
| ▸ | NPY2R | P49146 | 2/20 | 0.51 |
| ▸ | GHSR | Q92847 | 1/20 | 0.51 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.50 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.50 |
| ▸ | RXFP4 | Q8TDU9 | 1/20 | 0.49 |
| ▸ | RXFP3 | Q9NSD7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20402542 | 1.00 | MC4R (0.53) | MC4RMC1RMC3RTEAD1KLK7 | |
| SCHEMBL23056722 | 0.99 | TEAD1 (0.53) | MC4RMC1RMC3RTEAD1KLK7 | |
| SCHEMBL27014090 | 0.99 | TEAD1 (0.53) | MC4RMC1RMC3RTEAD1KLK7 | |
| SCHEMBL20003971 | 0.98 | GLP1R (0.51) | MC4RMC1RMC3RTEAD1KLK7 | |
| SCHEMBL20003981 | 0.97 | MC4R (0.50) | MC4RMC1RMC3RTEAD1KLK7 | |
| SCHEMBL23056750 | 0.95 | GLP1R (0.51) | MC4RMC1RKLK7GLP1RGCGR | |
| SCHEMBL26952437 | 0.93 | MC4R (0.59) | MC4RMC1RMC3RTEAD1GLP1R | |
| SCHEMBL20003753 | 0.91 | PRLHR (0.58) | GLP1RGCGRNPY2REPHA2RXFP4 | |
| SCHEMBL29393563 | 0.78 | F11 (0.56) | MC4RMC1RMC3RKLK7GLP1R | |
| SCHEMBL24625820 | 0.77 | KLK7 (0.53) | KLK7EPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240016895-A1 | HEPCIDIN MIMETICS FOR TREATMENT OF SICKLE CELL DISEASE | PROTAGONIST THERAPEUTICS, INC. | 2024-01-18 | — | — | US | disclosed |
| US-10030061-B2 | Hepcidin analogues and uses thereof | PROTAGONIST THERAPEUTICS, INC. (US) | 2018-07-24 | — | — | US | disclosed |
| US-20180086811-A1 | HEPCIDIN ANALOGUES AND USES THEREOF | PROTAGONIST THERAPEUTICS, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10030061-B2 | Hepcidin analogues and uses thereof | HAMP, SLC40A1, FTH1 | MC4R 917/4885MC1R 281/4885MC3R 976/4885 |
| US-20240016895-A1 | HEPCIDIN MIMETICS FOR TREATMENT OF SICKLE CELL DISEASE | HAMP, HBG1, HBG2 | MC4R 1409/4885MC1R 487/4885MC3R 1549/4885 |
| US-20180086811-A1 | HEPCIDIN ANALOGUES AND USES THEREOF | HAMP, SLC40A1, FTH1 | MC4R 925/4885MC1R 282/4885MC3R 972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.