Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24840305 | 0.92 | SMN1; SMN2 (0.39) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL19308856 | 0.90 | NPC1 (0.48) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL19954923 | 0.83 | NPC1 (0.40) | RAB9ANPC1SMN1; SMN2ALDH1A1SCN4A | |
| SCHEMBL21871342 | 0.81 | RAB9A (0.43) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20049378 | 0.77 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24420726 | 0.76 | SMN1; SMN2 (0.51) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL19966707 | 0.76 | SMN1; SMN2 (0.51) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL26340292 | 0.76 | OGA (0.36) | SMN1; SMN2KDM4EALDH1A1OGA | |
| SCHEMBL29870814 | 0.74 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL266440 | 0.74 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180085386-A1 | URIDINE MONOPHOSPHATE AND TRIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS OF USE | TUFTS UNIVERSITY | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180085386-A1 | URIDINE MONOPHOSPHATE AND TRIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS OF USE | P2RY6, UPP1, UMPS | RAB9A 965/4885NPC1 1808/4885SMN1; SMN2 410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.