Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | HCK | P08631 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25836231 | 0.85 | MET (0.38) | METNQO2DYRK1AJAK2PIK3CA | |
| SCHEMBL22109191 | 0.85 | MET (0.38) | METNQO2DYRK1AJAK2PIK3CA | |
| SCHEMBL29317548 | 0.83 | MET (0.37) | METNQO2DYRK1AJAK2PIK3CA | |
| SCHEMBL29315788 | 0.80 | MET (0.40) | METNQO2DYRK1AJAK2HCRTR2 | |
| SCHEMBL29315243 | 0.78 | MET (0.34) | METNQO2DYRK1AJAK2PIK3CA | |
| SCHEMBL29314918 | 0.74 | MET (0.36) | METNQO2DYRK1AJAK2PIK3CA | |
| SCHEMBL21801854 | 0.71 | MET (0.78) | METNQO2 | |
| SCHEMBL20004072 | 0.71 | MET (0.78) | METNQO2 | |
| SCHEMBL30733000 | 0.71 | MET (0.78) | METNQO2 | |
| SCHEMBL21167598 | 0.70 | MET (0.48) | METNQO2HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515418-B1 | USE OF C-MET INHIBITORS TO TREAT CANCERS HARBOURING MET MUTATIONS | ASTRAZENECA AB (SE) | 2021-04-14 | — | — | EP | disclosed |
| WO-2018055029-A1 | USE OF C-MET INHIBITORS TO TREAT CANCERS HARBOURING MET MUTATIONS | ASTRAZENECA AB (SE) | 2018-03-29 | — | — | WO | disclosed |