Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20004070 | 0.85 | MET (0.41) | METNQO2JAK2DYRK1APIK3CA | |
| SCHEMBL22109191 | 0.83 | MET (0.38) | METNQO2JAK2DYRK1APIK3CA | |
| SCHEMBL29317548 | 0.81 | MET (0.37) | METNQO2JAK2DYRK1APIK3CA | |
| SCHEMBL21167379 | 0.81 | MAPK8 (0.42) | METNQO2MAPK8JAK2DYRK1A | |
| SCHEMBL29315243 | 0.79 | MET (0.34) | METNQO2JAK2DYRK1APIK3CA | |
| SCHEMBL29315788 | 0.78 | MET (0.40) | METNQO2JAK2DYRK1AFGFR1 | |
| SCHEMBL29314918 | 0.73 | MET (0.36) | METNQO2JAK2DYRK1APIK3CA | |
| SCHEMBL25426802 | 0.72 | MET (0.72) | METNQO2 | |
| SCHEMBL12487598 | 0.72 | MET (0.72) | METNQO2 | |
| SCHEMBL1832761 | 0.69 | DYRK1A (0.58) | DYRK1APIK3CACHEK1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849977-B1 | IMPROVED METHOD FOR THE MANUFACTURE OF 3-[(1S)-1-IMIDAZO[1,2-A]PYRIDIN-6-YLETHYL]-5-(1-METHYLPYRAZOL-4-YL)TRIAZOLO[4,5-B]PYRAZINE AND POLYMORPHIC FORMS THEREOF | ASTRAZENECA AB (SE) | 2023-07-19 | — | — | EP | disclosed |