SCHEMBL20004527

SCHEMBL20004527

CN(C)c1cc(C#Cc2cc3c([nH]2)=NCCC=3)ccc1F

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SNCA P37840 9/20 0.37
MAPT P10636 5/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21147267 0.82 SNCA (0.51) SNCAMAPT
SCHEMBL20004453 0.81 SNCA (0.36) SNCAMAPT
SCHEMBL20005146 0.79 SNCA (0.36) SNCAMAPT
SCHEMBL20005013 0.78 GRM5 (0.40)
SCHEMBL21147086 0.76 GRM5 (0.41) SNCAMAPT
SCHEMBL20004555 0.76 APP (0.39) SNCAMAPT
SCHEMBL20005161 0.74 GRM5 (0.36)
SCHEMBL22537542 0.74 SNCA (0.39) SNCAMAPT
SCHEMBL21147289 0.73 PIK3CA (0.38)
SCHEMBL20005163 0.73 MAPT (0.44) SNCAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3515912-B1 COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES CENTRE NAT RECH SCIENT (FR) 2020-10-14 EP disclosed
WO-2018055316-A1 COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2018-03-29 WO disclosed