SCHEMBL20004879

SCHEMBL20004879

Cc1ccc(-c2cc(C)c(C#Cc3ccc(-c4ccc5cc(C)ccc5c4)cc3)cc2F)cc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.34
CYP1A2 P05177 2/20 0.33
CYP2A6 P11509 2/20 0.33
PTGS2 P35354 2/20 0.31
ESR1 P03372 2/20 0.31
ESR2 Q92731 2/20 0.31
MAPT P10636 1/20 0.31
CYP2C19 P33261 1/20 0.31
AAK1 Q2M2I8 1/20 0.31
PTGS1 P23219 1/20 0.31
AR P10275 1/20 0.31
ADORA3 P0DMS8 1/20 0.31
MAOB P27338 1/20 0.31
KCNH2 Q12809 2/20 0.31
CYP11B1 P15538 1/20 0.30
CYP11B2 P19099 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
CA12 O43570 1/20 0.30
CA2 P00918 1/20 0.30
CA9 Q16790 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20005287 0.91 ESR1 (0.38) FFAR1ESR1ESR2AAK1CYP11B1
SCHEMBL20004878 0.85 HRH3 (0.38) FFAR1
SCHEMBL20005267 0.84 RARA (0.39) FFAR1CYP1A2MAPTCYP2C19
SCHEMBL20004894 0.84 RARA (0.39) FFAR1CYP1A2MAPTCYP2C19
SCHEMBL20004586 0.84 GRM5 (0.37) PTGS2AAK1CYP11B1CYP11B2
SCHEMBL20005285 0.83 FFAR1 (0.40) FFAR1
SCHEMBL20004870 0.83 FFAR1 (0.45) FFAR1CYP1A2CYP2A6
SCHEMBL20005225 0.82 FFAR1 (0.46) FFAR1CYP1A2CYP2A6
SCHEMBL19999503 0.80 FFAR4 (0.39) FFAR1MAPTCYP11B1CYP11B2
SCHEMBL19999533 0.80 FFAR1 (0.33) FFAR1PTGS2AAK1ARKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed