SCHEMBL20005510

SCHEMBL20005510

CSc1ccccc1/C=C\C=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 4/20 0.52
CCND1 P24385 4/20 0.52
ALOX5 P09917 2/20 0.49
ABCB1 P08183 2/20 0.46
BACE1 P56817 1/20 0.45
ALDH1A1 P00352 4/20 0.43
LMNA P02545 2/20 0.43
TRPA1 O75762 1/20 0.43
MAPK1 P28482 1/20 0.43
PTGES2 Q9H7Z7 1/20 0.42
CCNB2 O95067 2/20 0.42
CDK1 P06493 2/20 0.42
CCNB1 P14635 2/20 0.42
CCNB3 Q8WWL7 2/20 0.42
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
THRB P10828 1/20 0.36
BLM P54132 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20099354 0.80 ALOX5 (0.45) CDK4CCND1ALOX5ABCB1BACE1
SCHEMBL173014 0.79 LMNA (0.55) ALOX5ABCB1BACE1ALDH1A1LMNA
SCHEMBL29517618 0.79 LMNA (0.55) ALOX5ABCB1BACE1ALDH1A1LMNA
SCHEMBL11070320 0.78 CDK4 (0.70) CDK4CCND1ALOX5ALDH1A1LMNA
SCHEMBL16476616 0.78 CDK4 (0.70) CDK4CCND1ALOX5ALDH1A1LMNA
SCHEMBL16935337 0.77 LMNA (0.52) ALOX5ABCB1BACE1ALDH1A1LMNA
SCHEMBL10060043 0.77 ALOX5 (0.49) ALOX5ABCB1BACE1ALDH1A1LMNA
SCHEMBL13012175 0.76 PTGES2 (0.52) ALOX5ABCB1BACE1ALDH1A1LMNA
SCHEMBL17241393 0.76 CDK4 (0.47) CDK4CCND1ALOX5ALDH1A1LMNA
SCHEMBL2095746 0.75 ALOX5 (0.47) ALOX5ABCB1BACE1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2771488-B1 CARBONIC ANHYDRASE IX-RELATED MARKERS AND USE THEREOF SIGNALCHEM LIFESCIENCES CORP (CA) 2018-03-28 EP disclosed