SCHEMBL2000685

SCHEMBL2000685

CCCC(=O)Oc1c(F)c(F)cc(F)c1F

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.41
ALDH1A1 P00352 3/20 0.41
KDM4E B2RXH2 3/20 0.40
KMT2A Q03164 2/20 0.40
BCL9 O00512 1/20 0.40
CTNNB1 P35222 1/20 0.40
GLA P06280 1/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 2/20 0.37
HTT P42858 1/20 0.37
CA1 P00915 2/20 0.36
CA2 P00918 2/20 0.36
CA4 P22748 2/20 0.36
AKR1B1 P15121 1/20 0.36
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
RAB9A P51151 1/20 0.34
PDGFRB P09619 1/20 0.34
PDGFRA P16234 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1998098 0.89 KMT2A (0.44) ALOX15KDM4EKMT2AAKR1B1
SCHEMBL28506184 0.87 ALOX15 (0.46) ALOX15KDM4EKMT2AMAPTAKR1B1
SCHEMBL17337902 0.86 KMT2A (0.40) ALDH1A1KDM4EKMT2AMAPTHTT
SCHEMBL17373963 0.86 VCAM1 (0.38) ALOX15ALDH1A1KDM4EKMT2AMAPT
SCHEMBL27239124 0.86 DGKA (0.46) ALOX15KMT2AMAPT
SCHEMBL15236082 0.86 DGKA (0.46) ALOX15KMT2AMAPT
SCHEMBL1996675 0.85 BCL9 (0.41) ALOX15ALDH1A1KDM4EKMT2ABCL9
SCHEMBL890351 0.85 MAPT (0.37) ALDH1A1KDM4EKMT2AMAPTHTT
SCHEMBL19402698 0.85 VCAM1 (0.43) ALDH1A1KDM4EKMT2AMAPTHTT
SCHEMBL1995471 0.84 ESR1 (0.40) ALOX15ALDH1A1KDM4EKMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
US-11859021-B2 Compounds for regulating trained immunity, and their methods of use ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2024-01-02 US disclosed
WO-2020190731-A1 IMMUNOCONJUGATES TARGETING HER2 BOLT BIOTHERAPEUTICS, INC. (US) 2020-09-24 WO disclosed
US-20170197916-A1 FUNCTIONALIZED PEGYLATED CYANINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF BroadPharm (US) 2017-07-13 US disclosed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US disclosed
CN-102186921-B Fluorine-containing copolymer composition and process for production thereof ASAHI GLASS CO LTD 2014-01-15 CN disclosed
EP-2338935-B1 FLUORINE-CONTAINING COPOLYMER COMPOSITION AND PROCESS FOR PRODUCTION THEREOF ASAHI GLASS CO LTD (JP) 2012-12-12 EP disclosed
CN-102186921-A Fluorine-containing copolymer composition and process for production thereof ASAHI GLASS CO LTD 2011-09-14 CN disclosed
US-20110172336-A1 FLUOROCOPOLYMER COMPOSITION AND ITS PRODUCTION PROCESS ASAHI GLASS COMPANY, LIMITED (JP) 2011-07-14 US disclosed
EP-2338935-A1 FLUORINE-CONTAINING COPOLYMER COMPOSITION AND PROCESS FOR PRODUCTION THEREOF ASAHI GLASS COMPANY, LIMITED (JP) 2011-06-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170197916-A1 FUNCTIONALIZED PEGYLATED CYANINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF ABL1, EGFR, ALB ALOX15 3507/4885ALDH1A1 1441/4885KDM4E 779/4885
US-11859021-B2 Compounds for regulating trained immunity, and their methods of use MYD88, CD74, IRF3 ALOX15 159/4885ALDH1A1 1202/4885KDM4E 2350/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.