Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007241 | 0.85 | HTR2A (0.39) | POLBALDH1A1CYP2D6SMN1; SMN2TRPV4 | |
| SCHEMBL20007247 | 0.84 | TRPV4 (0.46) | TRPV4NAMPT | |
| SCHEMBL23613847 | 0.82 | TRPV4 (0.57) | TRPV4NAMPTGAA | |
| SCHEMBL24025448 | 0.79 | POLB (0.65) | POLBALDH1A1CYP2D6CHRM1SMN1; SMN2 | |
| SCHEMBL24058307 | 0.79 | POLB (0.61) | POLBALDH1A1CYP2D6CHRM1SMN1; SMN2 | |
| SCHEMBL20007703 | 0.78 | TRPV4 (0.43) | ALDH1A1SMN1; SMN2TRPV4LMNAHTT | |
| SCHEMBL24025485 | 0.76 | POLB (0.60) | POLBALDH1A1CYP2D6CHRM1SMN1; SMN2 | |
| SCHEMBL24025476 | 0.76 | POLB (0.60) | POLBALDH1A1CYP2D6CHRM1SMN1; SMN2 | |
| SCHEMBL29693770 | 0.75 | POLB (0.59) | POLBALDH1A1CYP2D6CHRM1SMN1; SMN2 | |
| SCHEMBL29693719 | 0.75 | POLB (0.71) | POLBALDH1A1CYP2D6CHRM1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |