Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RBP1 | P09455 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007441 | 0.85 | POLB (0.56) | ALDH1A1SMN1; SMN2TRPV4GAAPOLB | |
| SCHEMBL20007247 | 0.84 | TRPV4 (0.46) | HTR2ATRPV4 | |
| SCHEMBL23613847 | 0.82 | TRPV4 (0.57) | HTR2ATRPV4GAAKDM4E | |
| SCHEMBL20007703 | 0.80 | TRPV4 (0.43) | HTR2AALDH1A1SMN1; SMN2TRPV4GAA | |
| SCHEMBL20007693 | 0.79 | TRPV4 (0.41) | ALDH1A1SMN1; SMN2TRPV4POLBMEN1 | |
| SCHEMBL23613990 | 0.79 | TRPV4 (0.41) | ALDH1A1SMN1; SMN2TRPV4POLBMEN1 | |
| SCHEMBL23613906 | 0.73 | TRPV4 (0.44) | HTR2ATRPV4GAAKDM4E | |
| SCHEMBL23613908 | 0.73 | TRPV4 (0.44) | HTR2ATRPV4GAAKDM4E | |
| SCHEMBL23613972 | 0.72 | HTR2A (0.41) | HTR2AALDH1A1SMN1; SMN2GAAPOLB | |
| SCHEMBL23614038 | 0.72 | RBP1 (0.36) | ALDH1A1SMN1; SMN2GAAPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |