Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 6/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 10/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23613908 | 0.89 | TRPV4 (0.44) | TRPV4NAMPTPSEN1PSEN2APH1B | |
| SCHEMBL23613906 | 0.89 | TRPV4 (0.44) | TRPV4NAMPTPSEN1PSEN2APH1B | |
| SCHEMBL20007703 | 0.86 | TRPV4 (0.43) | TRPV4HTR2A | |
| SCHEMBL20007441 | 0.84 | POLB (0.56) | TRPV4NAMPT | |
| SCHEMBL20007241 | 0.84 | HTR2A (0.39) | TRPV4HTR2A | |
| SCHEMBL23613847 | 0.81 | TRPV4 (0.57) | TRPV4NAMPTHTR2A | |
| SCHEMBL23613995 | 0.79 | TRPV4 (0.42) | TRPV4 | |
| SCHEMBL23613997 | 0.79 | TRPV4 (0.42) | TRPV4 | |
| SCHEMBL23613972 | 0.79 | HTR2A (0.41) | NAMPTHTR2A | |
| SCHEMBL20007244 | 0.79 | TRPV4 (0.46) | TRPV4PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |