Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 9/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RBP1 | P09455 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007247 | 0.86 | TRPV4 (0.46) | TRPV4HTR2A | |
| SCHEMBL20007241 | 0.80 | HTR2A (0.39) | TRPV4SMN1; SMN2ALDH1A1LMNAGAA | |
| SCHEMBL20007441 | 0.78 | POLB (0.56) | TRPV4SMN1; SMN2ALDH1A1LMNAGAA | |
| SCHEMBL20007244 | 0.77 | TRPV4 (0.46) | TRPV4GAA | |
| SCHEMBL23613908 | 0.76 | TRPV4 (0.44) | TRPV4GCKGAAHTR2A | |
| SCHEMBL23613906 | 0.76 | TRPV4 (0.44) | TRPV4GCKGAAHTR2A | |
| SCHEMBL23613972 | 0.75 | HTR2A (0.41) | SMN1; SMN2ALDH1A1LMNAGAAHTT | |
| SCHEMBL23613847 | 0.75 | TRPV4 (0.57) | TRPV4GAAHTR2A | |
| SCHEMBL20007693 | 0.73 | TRPV4 (0.41) | TRPV4SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL23613990 | 0.73 | TRPV4 (0.41) | TRPV4SMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |